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FLAMEL APPOINTS JANIK BLOUIN
GENERAL MANAGER AND BOARD MEMBER

Lyon, France, June 8, 1999 - Flamel Technologies (Nasdaq: FLML) today announced the appointment of Ms. Janik Blouin to the newly created post of General Manager and her election to the Company’s Board of Directors.

"We are very pleased to welcome Janik Blouin to Flamel. Her extensive operational experience and her background in the pharmaceutical industry will be extremely valuable to the Company, as we continue working toward achieving our aggressive innovative and business objectives," explained Dr. Gerard Soula, Flamel’s founder and President and Chief Executive Officer." Her presence will allow me to make Flamel’s long-term growth strategy and increasing shareholder value my top priorities."

The role of General Manager has been created to strengthen Flamel’s focus as a product-oriented company. Ms. Blouin will manage Flamel’s day-to-day operations and will, together with Dr. Soula, oversee the Company’s business development activities. Ms. Blouin, who has over twenty years of experience in the pharmaceutical industry, joins Flamel from 3M Sante, France, where she had been the General Manager since 1997. Prior to assuming that role, Ms. Blouin held a number of other positions in 3M Sante, including Business and Marketing Manager. Her earlier experience includes business and marketing experience at Amour Montagu (later Rorer), Merck Sharpe & Dohme, France, and ICI Pharmaceuticals.