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Flamel Technologies Announces Funded Feasibility Study With a Major Bio-Pharmaceutical Company using its Medusa® Technology.  

Lyon, France, November 14, 2001 - Flamel Technologies (NASDAQ:FLML) announced today that it has entered into an agreement with an undisclosed major worldwide bio-pharmaceutical  company to investigate the application of its Medusa® controlled-release protein and peptide delivery technology to an existing and specific class of proteins.

The work on the application of Flamel's Medusa technology to this protein will be fully-funded by Flamel's partner. Terms of the agreement were not disclosed.

“We are very pleased to have found a partner to join us in our work with his important class of proteins," said Dr. Gerard Soula, president and chief executive officer of Flamel Technologies. “This is our third partnership for Medusa®. Like our flagship agreement with insulin with Novo Nordisk, it has been partnered after initial work performed internally at Flamel. We believe the interest and involvement of our seven major pharmaceutical partners worldwide, some with Medusa® and others with Micropump®, is important in the development of applications of our technology to a wide variety of compounds.”

Flamel Technologies S.A. is a biopharmaceutical company principally engaged in the development of two unique polymer-based delivery technologies for medical applications. Flamel’s Medusa® nano-encapsulation technology is designed to deliver therapeutic proteins. Micropump® is a controlled release technology for the oral administration of small molecule drugs. Flamel’s expertise in polymer science has also been instrumental in the development of a photochromic eyeglass lens product now marketed by Corning Inc. 

This document contains a number of matters, particularly as related to the status of various research projects and technology platforms, that constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. The presentation reflects the current view of management with respect to future events and is subject to risks and uncertainties that could cause actual results to differ materially from those contemplated in such forward-looking statements. These risks include risks that products in the development stage may not achieve scientific objectives or milestones or meet stringent regulatory requirements, uncertainties regarding market acceptance of products in development, the impact of competitive products and pricing, and the risks associated with Flamel’s reliance on outside parties and key strategic alliances. These and other risks are described more fully in Flamel’s Annual Report on the Securities and Exchange Commission Form 20-F for the year ended December 31, 1999.