Lyon, France – Octobre 24, 2005 – Flamel Technologies S.A.(NASDAQ: FLML) announced the election of three new members to its Board of Directors today, as well as the results of its extraordinary general meeting held today.

The new directors are:

Mr. Frédéric Lemoine who currently serves as the Chairman of the Supervisory Board of Areva, a world-leader in the nuclear industry.
He also serves as Chairman of the Audit Committee and Director of Groupama, the French insurance company, as well as being a Senior Advisor for McKinsey. From June 2002 to May 2004, he worked with the President of the French Republic as Deputy General Secretary for Economic Affairs. Mr. Lemoine is a graduate of the Haute Etudes Commerciales School of Management (HEC), of the Institut d'Etudes Politiques (IEP) and the Ecole Nationale d'Administration (ENA).

Mr. John L. Vogelstein is Vice Chairman of Warburg Pincus and a highly regarded investor and advisor.
He has been active in the field of finance for more 50 years. Prior to joining Warburg Pincus, he was a Partner of Lazard Freres & Co. Mr. Vogelstein is a director of Journal Register Company and Mattel, Inc. He is Chairman of the Board of Trustees of Prep for Prep; Vice Chairman of the Board of Overseers of the Leonard N. Stern School of Business; a Trustee of New York University, The Jewish Museum and Congregation Emanu-El; a member of the Board of Pardee Rand Graduate School and Gillen Brewer School; Chairman of the Investment Committee of the New York City Ballet, and a member of the Advisory Board of Christie's.

Mr. Stephen H. Willard is the Chief Executive Officer of Flamel Technologies.
From August, 2000 until being named CEO by the Board of Directors in June, 2005, Mr. Willard served as Executive Vice President, Chief Financial Officer, and General Counsel of Flamel. Prior to joining Flamel, Mr. Willard was employed as a vice president of Biovail Corporation. He also worked as an investment banker at Credit Suisse First Boston and as an attorney with Gibson, Dunn & Crutcher LLP and Shearman & Sterling LLP. He is a graduate of Yale Law School (1985) and Williams College (1982). Mr. Willard also serves as an outside director of E*TRADE Financial Corporation.

The shareholder assembly also voted by a large majority to approve all other resolutions submitted and recommended for approval by the Board of Directors.

Elie Vannier, non-executive chairman of the board of Flamel, said "We are delighted that Messrs. Lemoine and Vogelstein will be joining our Board of Directors. They bring important expertise to our Board and will help Flamel to further achieve its potential. As regards Stephen Willard, it is a clear sign of the trust that the Board wishes to express to its chief executive officer and the whole management team of Flamel. We appreciate the support of our shareholders in these important matters."

Flamel Technologies, S.A. is a biopharmaceutical company principally engaged in the development of two unique polymer-based delivery technologies for medical applications. Flamel's Medusa® technology is designed to deliver controlled-release formulations of therapeutic proteins and peptides. Micropump® is a controlled release and taste-masking technology for the oral administration of small molecule drugs.

This document contains a number of matters, particularly as related to the status of various research projects and technology platforms, that constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. The document reflects the current view of management with respect to future events and is subject to risks and uncertainties that could cause actual results to differ materially from those contemplated in such forward-looking statements. These risks include risks that products in the development stage may not achieve scientific objectives or milestones or meet stringent regulatory requirements, uncertainties regarding market acceptance of products in development, the impact of competitive products and pricing, and the risks associated with Flamel's reliance on outside parties and key strategic alliances. These and other risks are described more fully in Flamel's Annual Report on the Securities and Exchange Commission Form 20-F for the year ended December 31, 2004.

Contact:

Michel Finance, Chief Financial Officer
Tel: (011) (33) 4-7278- 3434
Fax: (011) (33) 4-7278-3435
E-mail: finance@flamel.com

Or

Charles Marlio, Director of Strategic Planning and Investor Relations
FRANCE (011) 33-4-72-78-34-23
US (1) 202-862-8400
Fax: 202-862-3933
E-mail: marlio@flamel.com