Lyon, France – March 2, 2006 – Flamel Technologies S.A.(NASDAQ: FLML) expects to release its fourth quarter and 2005 annual financial results on Tuesday, March 7th after the market close. A conference call to discuss Flamel's fourth quarter and 2005 annual results as well as the Company's pipeline and current outlook has been scheduled for Wednesday, March 8th at 8:30 AM (EDT). A question and answer period is expected to follow the discussion of results.

To participate in the conference call, investors in the US and Canada are invited to dial 1-800-374-1498. International callers are invited to call 1-706-634-7261. The Conference ID # is 6135376.

Flamel Technologies, S.A. is a biopharmaceutical company principally engaged in the development of two unique polymer-based delivery technologies for medical applications. Micropump® is a controlled release and taste- masking technology for the oral administration of small molecule drugs. Flamel's Medusa® technology is designed to deliver controlled-release formulations of therapeutic proteins.

This press release contains "forward-looking statements" as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements are based on management's current expectations and involve significant risks and uncertainties that may cause results to differ materially from those set forth in the statements. Among other risks, there can be no guarantee that the product described in this release will receive regulatory approval, or that it will prove to be commercially successful. This and other risk factors are discussed in the company's 2004 Annual Report on Form 20-F and in the company's periodic reports on Form 6-K. We undertake no obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or otherwise. These and other risks are described more fully in Flamel's Annual Report on the Securities and Exchange Commission Form 20-F for the year ended December 31, 2004.

Contact:

Stephen H. Willard, Chief Executive Officer
Tel: (1) 202-862-8400
Fax: (1) 202-862-3933

Michel Finance, Chief Financial Officer
Tel: (011) (33) 4-7278-3434
Fax: (011) (33) 4-7278-3435
E-mail: finance@flamel.com

Charles Marlio, Director of Strategic Planning and Investor Relations
FRANCE (011) 33-4-72-78-34-34
US (1) 202-862-8400
Fax: 202-862-3933
E-mail: marlio@flamel.com