Flamel's revenues during the quarter included the first royalties received from GlaxoSmithKline (NYSE: GSK) on sales of COREG CR, which was launched on March 22nd.

For the first quarter, Flamel reported total revenues of $9.6 million versus $5.1 million in the year-ago period. Product sales and services, consisting of COREG CR microparticle shipments to GSK, totaled $5.4 million. Flamel's 2007 first quarter license and research revenues of $3.1 million included a $1 million milestone payment received from GSK; license and research revenues in the year-ago period were $4.9 million and included $2 million in milestones from GSK. Other revenues of $1.1 million increased from $0.2 million in the year-ago quarter and included royalties on the sale of COREG CR.

Operational expenses were $19.1 million, versus $15.2 million in the year-ago quarter. Costs of goods and services sold were $4.5 million and comprised sales of COREG CR microparticles, as compared to $1.8 million in the first quarter of 2006. Costs and expenses of Flamel's research and development were $10.6 million, compared to $9.5 million in the year-ago quarter. SG&A expenses during the quarter were $4.1 million versus $3.9 million in the year-ago quarter.

Net loss for the quarter was ($9.1) million, compared to net loss of ($9.7) million in the first quarter of 2006. Net loss per share (basic) for the first quarter of 2006 was ($0.38), compared to net loss per share (basic) in the year-ago period of ($0.41). Cash and marketable securities at the end of the first quarter totaled $52.7 million, reflecting the strong financial position of the Company.

Stephen H. Willard, Flamel's Chief Executive Officer, stated, "We are pleased with the early success of the COREG CR launch. Feedback from the cardiological community has been very positive. Physicians understand that the once-daily formulation of COREG CR offers key advantages to patients. It is well established that once-daily medications lead to greater patient compliance; non-compliance is one of the leading causes of hospitalization in heart failure patients. COREG CR delivers substantially the same peak and trough levels of carvedilol as the twice-a-day drug, taken as directed, but with a smoother release profile. Moreover, COREG CR has been observed to result in 24% fewer adverse events than immediate release Coreg in a crossover study conducted in hypertension patients. The success of COREG CR is generating positive interest in the Micropump platform from potential partners and interest in the Medusa® platform has also been renewed. We look forward to further positive developments with both platforms during 2007."

About Flamel Technologies

Flamel Technologies, S.A. is a biopharmaceutical company principally engaged in the development of two unique polymer-based delivery technologies for medical applications. Micropump® is a controlled release and taste-masking technology for the oral administration of small molecule drugs. Flamel's Medusa® technology is designed to deliver controlled-release formulations of therapeutic proteins.

A conference call to discuss earnings is scheduled for 8:30 AM EDT May 7, 2007.
The dial-in number (for investors in the U.S. and Canada) is 800-374-1498.
The conference ID number is 7441635.
International investors are invited to dial (1) 706-634-7261.

Coreg® is a registered trademark of GlaxoSmithKline.

This document contains a number of matters, particularly as related to the status of various research projects and technology platforms, that constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995.

The document reflects the current view of management with respect to future events and is subject to risks and uncertainties that could cause actual results to differ materially from those contemplated in such forward-looking statements.

These risks include risks that products in the development stage may not achieve scientific objectives or milestones or meet stringent regulatory requirements, uncertainties regarding market acceptance of products in development, the impact of competitive products and pricing, and the risks associated with Flamel's reliance on outside parties and key strategic alliances.